منابع مشابه
TRPM3, a biophysical enigma?
TRPM3 [TRP (transient receptor potential) melastatin 3] is one of the least investigated proteins of the TRP family of ion channels. Heterologously expressed TRPM3 channels are constitutively active, have an outwardly rectifying current-voltage relationship and are inhibited by intracellular Mg(2+) ions. Besides these rather common features, in which TRPM3 channels resemble the closely related ...
متن کاملTRPM3 Expression in Mouse Retina
Transient receptor potential (TRP) channels constitute a large family of cation permeable ion channels that serve crucial functions in sensory systems by transducing environmental changes into cellular voltage and calcium signals. Within the retina, two closely related members of the melastatin TRP family, TRPM1 and TRPM3, are highly expressed. TRPM1 has been shown to be required for the depola...
متن کاملPruriceptive spinothalamic tract neurons: Physiological properties
21 22 Itch of peripheral origin requires information transfer from the spinal cord to the brain for 23 perception. Here, primate spinothalamic tract (STT) neurons from lumbar spinal cord were 24 functionally characterized using in vivo electrophysiology to determine the role of these cells in 25 the transmission of pruriceptive information. 111 STT neurons were identified by antidromic 26 stimu...
متن کاملCharacterization of pruriceptive trigeminothalamic tract neurons in rats.
Rodent models of facial itch and pain provide a valuable tool for distinguishing between behaviors related to each sensation. In rats, pruritogens applied to the face elicit scratching using the hindlimb while algogens elicit wiping using the forelimb. We wished to determine the role of trigeminothalamic tract (VTT) neurons in carrying information regarding facial itch and pain to the forebrain...
متن کاملNpgrj_nmeth_1207 401..403
Fluorescence resonance energy transfer (FRET) with fluorescent proteins is a powerful method for detection of protein-protein interactions, enzyme activities and small molecules in the intracellular milieu. Aided by a new violet-excitable yellow-fluorescing variant of Aequorea victoria GFP, we developed dual FRET–based caspase-3 biosensors. Owing to their distinct excitation profiles, each FRET...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.07.403